When you are going on vacation, there is an option in some mail programs such as Outlook to reply with a message saying anything you want. After you turn on auto reply, there is a text field where you can type in your message. In general, this is what I have seen the most. Once again, the following is not spoken, but email language.
'I will be vacation until June 4th. I will be on email occasionally, but if you have an emergency, you can reach me at 555-555-5555. For information on financial reports, contact Suzy Mae. For information on quarterly earnings, contact Jim Beam. For other urgent matters, contact Billy McHale.'